J. F. Bardeau, A. S. Eberhardt, R. M. Nyquist, A. N. Parikh, A. P. Shreve, B. I. Swanson, Synthetic Metals 102, 1452 (1999)

Shifts in the main phase transition temperatures caused by a highly specific, protein-receptor interaction in a hybrid bilayer architecture are probed utilizing temperature programmed infrared vibrational spectroscopy. The specific case of cholera toxin attachment to glycolipid receptors embedded in a phospholipid outer layer at a hydrophobized silicon surface is investigated. Potential applications of the approach as a signal amplification method in biosensors will be discussed.