Membrane Photolithography: Patterning Fluid, Supported Lipid Bilayer Membranes in the Aqueous Phase

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Chanel K. Yee, Meri L. Amweg, Atul N. Parikh, Advanced Materials 6, 1184-1189, 2004

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A wet photolithography approach using light-activated, localized, oxidative chemistry can directly pattern fluid phospholipid bilayers submerged in aqueous phases. Targeted incorporation of secondary components within pattern voids (see Figure) allows many membrane dynamical processes to be probed and optically defined arrays of holes, functional membrane microdomains, and proteins embedded in a lipidic background can be designed.




DOI:10.1002/adma.200306498

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